Bonding layers for medical device surface coatings

Overview

Information

Number: 5997517
Application: 08/791440
Filing date: 01/27/1997
Issue date: 12/07/1999
Inventor(s): Richard J. Whitbourne

US Classification: 424/422; 424/475; 424/482; 427/2.3; 604/12; 604/265; 623/901

Citations

Boston Scientific (5)

Number	Title	Issue Date
5452726	Intravascular guide wire and method for manufacture thereof	1995/09/26
4841976	Steerable catheter guide	1989/06/27
5443907	Coating for medical insertion guides	1995/08/22
5662960	Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel	1997/09/02
5047045	Multi-section coaxial angioplasty catheter	1991/09/10

Becton, Dickinson and (5)

Number	Title	Issue Date
4990357	Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings	1991/02/05
4589873	Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby	1986/05/20
4678660	Thermoplastic polyurethane anticoagulant alloy coating	1987/07/07
5084315	Lubricious coatings, medical articles containing same and method for their preparation	1992/01/28
5013717	Blood compatible, lubricious article and composition and method therefor	1991/05/07

Dentsply International (3)

Number	Title	Issue Date
4906237	Method of forming an improved hydrophilic coating on a polymer surface	1990/03/06
4459317	Process for the preparation of a hydrophilic coating	1984/07/10
4585666	Preparation of hydrophilic coating	1986/04/29

Cordis (3)

Number	Title	Issue Date
5041100	Catheter and hydrophilic, friction-reducing coating thereon	1991/08/20
5041100	Catheter and hydrophilic, friction-reducing coating thereon	1991/08/20
4781703	Catheter assembly	1988/11/01

Hydromer (3)

Number	Title	Issue Date
4769013	Bio-effecting medical material and device	1988/09/06
4642267	Hydrophilic polymer blend	1987/02/10
4100309	Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same	1978/07/11

Scimed Life Systems (2)

Number	Title	Issue Date
4841976	Steerable catheter guide	1989/06/27
5662960	Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel	1997/09/02

NA (2)

Number	Title	Issue Date
4330956	Dual coated wire trolling line	1982/05/25
4143423	Surgical lubricants	1979/03/13

Angiotech International (2)

Number	Title	Issue Date
5331027	Lubricious hydrophilic coating, resistant to wet abrasion	1994/07/19
5525348	Coating compositions comprising pharmaceutical agents	1996/06/11

Terumo (2)

Number	Title	Issue Date
5670558	Medical instruments that exhibit surface lubricity when wetted	1997/09/23
4876126	Medical instrument and method for making	1989/10/24

University of Utah (1)

Number	Title	Issue Date
4557724	Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters	1985/12/10

DOW CHEMICAL (1)

Number	Title	Issue Date
5620738	Non-reactive lubicious coating process	1997/04/15

STEWART, H. FRANKLIN (1)

Number	Title	Issue Date
5429839	Method for grafting preformed hydrophillic polymers onto hydrophobic polymer substrates	1995/07/04

Cook (1)

Number	Title	Issue Date
5129890	Hydrophilically coated flexible wire guide	1992/07/14

Nec Tokin (1)

Number	Title	Issue Date
5069226	Catheter guidewire with pseudo elastic shape memory alloy	1991/12/03

Unomedical A/S (1)

Number	Title	Issue Date
5416131	Article with a coating having friction-reducing properties in wet condition as well as a method for the production of such a coated article	1995/05/16

CONGOLEUM (1)

Number	Title	Issue Date
4361626	Methods for bonding dissimilar synthetic polymeric materials and the products involved in and resulting from such methods	1982/11/30

High Voltage Engineering (1)

Number	Title	Issue Date
4055682	Catheter and the method of making	1977/10/25

cardinal health switzerland 515 (1)

Number	Title	Issue Date
4883699	Polymeric article having high tensile energy to break when hydrated	1989/11/28

Corning (1)

Number	Title	Issue Date
4087567	Anticoagulant coating method	1978/05/02

Astra Meditec (1)

Number	Title	Issue Date
4373009	Method of forming a hydrophilic coating on a substrate	1983/02/08

Abbott Laboratories (1)

Number	Title	Issue Date
4534363	Coating for angiographic guidewire	1985/08/13

Minnesota Mining and Manufacturing (1)

Number	Title	Issue Date
4977901	Article having non-crosslinked crystallized polymer coatings	1990/12/18

Hoechst (1)

Number	Title	Issue Date
4758475	Isocyanate-free polyurethane dispersions	1988/07/19

Tyndale Plains-Hunter (1)

Number	Title	Issue Date
4729914	Hydrophilic coating and substrate coated therewith	1988/03/08

Johnson & Johnson (1)

Number	Title	Issue Date
4381008	Methods of improving surface characteristics of extruded thermoplastic tubing and products produced thereby	1983/04/26

stryker european operations (1)

Number	Title	Issue Date
4884579	Catheter guide wire	1989/12/05

Merit Medical Systems (1)

Number	Title	Issue Date
4950257	Catheter introducer with flexible tip	1990/08/21

The United States of America as represented by the United States Energy (1)

Number	Title	Issue Date
3939049	Process for radiation grafting hydrogels onto organic polymeric substrates	1976/02/17

Baxter International (1)

Number	Title	Issue Date
4835003	Medical tubing with water-activated lubricating coating	1989/05/30

UBE Industries, (1)

Number	Title	Issue Date
4872867	Compositions having antithrombogenic properties and blood contact medical devices using the same	1989/10/10

Covidien (1)

Number	Title	Issue Date
4991602	Flexible guide wire with safety tip	1991/02/12

Superior Healthcare Group (1)

Number	Title	Issue Date
5061254	Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter	1991/10/29

Technicare (1)

Number	Title	Issue Date
4401124	Reflection enhancement of a biopsy needle	1983/08/30

LRC Products (1)

Number	Title	Issue Date
4482577	Coating process of elastomeric material	1984/11/13

Eastman Chemical (1)

Number	Title	Issue Date
5523095	Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends	1996/06/04

Advanced cardiovascular Systems (1)

Number	Title	Issue Date
4867174	Guidewire for medical use	1989/09/19

Ansell Healthcare Products (1)

Number	Title	Issue Date
5088125	Gloves	1992/02/18

Biocoat (1)

Number	Title	Issue Date
4959074	Method of hydrophilic coating of plastics	1990/09/25

Medtronic (1)

Number	Title	Issue Date
5160790	Lubricious hydrogel coatings	1992/11/03

University of Medicine and Dentistry of New Jersey (1)

Number	Title	Issue Date
4879135	Drug bonded prosthesis and process for producing same	1989/11/07

Abstract

Abstract

A medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers, polymers containing hydroxyl, amine, carboxyl, amide, or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants. Methods of coating and coating liquids are provided.

Assignees with Similar Patents

Boston Scientific (10)

Number	Title
6099563	Substrates, particularly medical devices, provided with bio-active/biocompatible coatings
6468649	Antimicrobial adhesion surface
101751019	Processes for producing polymer coatings through surface polymerization
101817980	Medical devices having coating with improved adhesion
101990733	ENDOPROSTHESIS COATING
102316389	MEDICAL DEVICES HAVING FLUORINE-CONTAINING POLYMER COATINGS WITH IMPROVED ADHESION
7942926
7931932	Processes for producing polymer coatings through surface polymerization
7919110	Medical device drug release regions containing non-covalently bound polymers
7105175	Implantable or insertable medical devices for controlled delivery of a therapeutic agent

IPXMEDICAL, LLC (6)

Number	Title
7771468	Medicated stent having multi-layer polymer coating
7771468	Medicated stent having multi-layer polymer coating
8287590	Medicated stent having multi-layer polymer coating
8287590	Medicated stent having multi-layer polymer coating
8101200	Targeted therapeutic agent release devices and methods of making and using the same
8101200	Targeted therapeutic agent release devices and methods of making and using the same

NA (6)

Number	Title
102423125	PHOTO-CURING OF THERMOPLASTIC COATINGS
102337031	Device Having a Hydrophilic Coating Comprising P-Toluene-Sulfonamide and a Method for the Preparation Thereof
102330765	COATINGS PREPARED FROM POLY(ETHYLENE OXIDE) AND PHOTO-INITATOR-CONTAINING SCAFFOLDS
102492914	FUNCTIONALIZED ADHESIVE MEDICAL GEL
102494919	Method of Preparing Polymeric Adhesive Compositions Utilizing the Mechanism of Ineraction Between the Polymer Components
102750423	Polymer-coated substrates for binding biomolecules and methods of making and using Thereof

Affinergy (5)

Number	Title
102288217	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
102292068	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
7972615	Peptide compositions for coating metal medical devices with vancomycin
102239549	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE
102184332	COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE

Advanced cardiovascular Systems (4)

Number	Title
7678143	Ethylene-carboxyl copolymers as drug delivery matrices
6824559	Ethylene-carboxyl copolymers as drug delivery matrices
100129453	Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device
6541116	Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device

Referenced by

Advanced cardiovascular Systems (186)

Number	Title	Issue Date
7601383	Coating construct containing poly (vinyl alcohol)	2009/10/13
6605114	Heparin delivery method	2003/08/12
6764505	Variable surface area stent	2004/07/20
6776792	Coated endovascular stent	2004/08/17
6790228	Coating for implantable devices and a method of forming the same	2004/09/14
6908624	Coating for implantable devices and a method of forming the same	2005/06/21
6926919	Method for fabricating a coating for a medical device	2005/08/09
6953560	Barriers for polymer-coated implantable medical devices and methods for making the same	2005/10/11
6982004	Electrostatic loading of drugs on implantable medical devices	2006/01/03
6986899	Composition for coating an implantable prosthesis	2006/01/17
6994867	Biocompatible carrier containing L-arginine	2006/02/07
7005137	Coating for implantable medical devices	2006/02/28
7011842	Polycationic peptide coatings and methods of making the same	2006/03/14
7014913	Rate-reducing membrane for release of an agent	2006/03/21
7022372	Compositions for coating implantable medical devices	2006/04/04
7033602	Polycationic peptide coatings and methods of coating implantable medical devices	2006/04/25
7056523	Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine	2006/06/06
7056591	Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same	2006/06/06
7063884	Stent coating	2006/06/20
7070798	Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine	2006/07/04
7077860	Method of reducing or eliminating thrombus formation	2006/07/18
7087263	Rare limiting barriers for implantable medical devices	2006/08/08
7094256	Coatings for implantable medical device containing polycationic peptides	2006/08/22
7115300	Method of coating implantable medical devices	2006/10/03
7166680	Blends of poly(ester amide) polymers	2007/01/23
7169173	Composite stent with regioselective material and a method of forming the same	2007/01/30
7169178	Stent with drug coating	2007/01/30
7175873	Rate limiting barriers for implantable devices and methods for fabrication thereof	2007/02/13
7198675	Stent mandrel fixture and method for selectively coating surfaces of a stent	2007/04/03
7202325	Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles	2007/04/10
7214759	Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same	2007/05/08
7217426	Coatings containing polycationic peptides for cardiovascular therapy	2007/05/15
7220816	Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same	2007/05/22
7223282	Remote activation of an implantable device	2007/05/29
7244443	Polymers of fluorinated monomers and hydrophilic monomers	2007/07/17
7247313	Polyacrylates coatings for implantable medical devices	2007/07/24
7247364	Coating for implantable medical devices	2007/07/24
7258891	Stent mounting assembly and a method of using the same to coat a stent	2007/08/21
7261946	Block copolymers of acrylates and methacrylates with fluoroalkenes	2007/08/28
7279174	Stent coatings comprising hydrophilic additives	2007/10/09
7285304	Fluid treatment of a polymeric coating on an implantable medical device	2007/10/23
7297159	Selective coating of medical devices	2007/11/20
7311980	Polyactive/polylactic acid coatings for an implantable device	2007/12/25
7318932	Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same	2008/01/15
7329366	Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability	2008/02/12
7329413	Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof	2008/02/12
7335391	Method for coating implantable devices	2008/02/26
7357793	Polymers of fluorinated and hydrophilic monomers	2008/04/15
7361726	Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles	2008/04/22
7364748	Controlled morphologies in polymer drug for release of drugs from polymer films	2008/04/29
7365133	Blends of poly(ester amide) polymers	2008/04/29
7387810	Method of forming rate limiting barriers for implantable devices	2008/06/17
7390497	Poly(ester amide) filler blends for modulation of coating properties	2008/06/24
7390523	Method of forming a diffusion barrier layer for implantable devices	2008/06/24
7396539	Stent coatings with engineered drug release rate	2008/07/08
7396541	Heparin prodrugs and drug delivery stents formed therefrom	2008/07/08
7419504	Poly(ester amide) block copolymers	2008/09/02
7431959	Method and system for irradiation of a drug eluting implantable medical device	2008/10/07
7435788	Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents	2008/10/14
7441513	Plasma-generated coating apparatus for medical devices and a method of coating deposition	2008/10/28
7449210	Electrostatic loading of drugs on implantable medical devices	2008/11/11
7455907	Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same	2008/11/25
7481835	Encapsulated covered stent	2009/01/27
7491233	Purified polymers for coatings of implantable medical devices	2009/02/17
7494665	Polymers containing siloxane monomers	2009/02/24
7507251	Blends of poly(ester amide) polymers	2009/03/24
7520891	Blends of poly(ester amide) polymers	2009/04/21
7538180	Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same	2009/05/26
7553377	Apparatus and method for electrostatic coating of an abluminal stent surface	2009/06/30
7560492	Polysulfone block copolymers as drug-eluting coating material	2009/07/14
7563324	System and method for coating an implantable medical device	2009/07/21
7563454	Coatings for implantable medical devices	2009/07/21
7563483	Methods for fabricating a coating for implantable medical devices	2009/07/21
7563780	Heparin prodrugs and drug delivery stents formed therefrom	2009/07/21
7572336	Clamp mandrel fixture and a method of using the same to minimize coating defects	2009/08/11
7588642	Abluminal stent coating apparatus and method using a brush assembly	2009/09/15
7591841	Implantable devices for accelerated healing	2009/09/22
7601384	Method of coating implantable medical devices	2009/10/13
7604700	Stent mandrel fixture and method for selectively coating surfaces of a stent	2009/10/20
7604818	Polymers of fluorinated monomers and hydrocarbon monomers	2009/10/20
7622070	Method of manufacturing an implantable polymeric medical device	2009/11/24
7622146	Rate limiting barriers for implantable devices and methods for fabrication thereof	2009/11/24
7632307	Abluminal, multilayer coating constructs for drug-delivery stents	2009/12/15
7632914	Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents	2009/12/15
7637941	Endothelial cell binding coatings for rapid encapsulation of bioerodable stents	2009/12/29
7638156	Apparatus and method for selectively coating a medical article	2009/12/29
7645474	Method and system of purifying polymers for use with implantable medical devices	2010/01/12
7648725	Clamp mandrel fixture and a method of using the same to minimize coating defects	2010/01/19
7648727	Methods for manufacturing a coated stent-balloon assembly	2010/01/19
7666223	Stent with drug coating	2010/02/23
7674493	Method of making a variable surface area stent	2010/03/09
7678143	Ethylene-carboxyl copolymers as drug delivery matrices	2010/03/16
7682647	Thermal treatment of a drug eluting implantable medical device	2010/03/23
7682648	Methods for forming polymeric coatings on stents	2010/03/23
7682669	Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device	2010/03/23
7691401	Poly(butylmethacrylate) and rapamycin coated stent	2010/04/06
7700659	Implantable devices formed of non-fouling methacrylate or acrylate polymers	2010/04/20
7704544	System and method for coating a tubular implantable medical device	2010/04/27
7713637	Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer	2010/05/11
7732535	Coating for controlled release of drugs from implantable medical devices	2010/06/08
7735449	Stent fixture having rounded support structures and method for use thereof	2010/06/15
7758880	Biocompatible polyacrylate compositions for medical applications	2010/07/20
7758881	Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device	2010/07/20
7766884	Polymers of fluorinated monomers and hydrophilic monomers	2010/08/03
7772359	Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents	2010/08/10
7775178	Stent coating apparatus and method	2010/08/17
7776926	Biocompatible coating for implantable medical devices	2010/08/17
7785512	Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices	2010/08/31
7785647	Methods of providing antioxidants to a drug containing product	2010/08/31
7786249	Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents	2010/08/31
7794743	Polycationic peptide coatings and methods of making the same	2010/09/14
7795467	Bioabsorbable, biobeneficial polyurethanes for use in medical devices	2010/09/14
7803394	Polycationic peptide hydrogel coatings for cardiovascular therapy	2010/09/28
7803406	Polycationic peptide coatings and methods of coating implantable medical devices	2010/09/28
7807210	Hemocompatible polymers on hydrophobic porous polymers	2010/10/05
7807211	Thermal treatment of an implantable medical device	2010/10/05
7807722	Biobeneficial coating compositions and methods of making and using thereof	2010/10/05
7820190	Coating for implantable devices and a method of forming the same	2010/10/26
7820229	Method of coating a stent	2010/10/26
7820732	Methods for modulating thermal and mechanical properties of coatings on implantable devices	2010/10/26
7823533	Stent fixture and method for reducing coating defects	2010/11/02
7824440	Stent with drug coating	2010/11/02
7824441	Stent with drug coating	2010/11/02
7862495	Radiation or drug delivery source with activity gradient to minimize edge effects	2011/01/04
7867547	Selectively coating luminal surfaces of stents	2011/01/11
7875073	Block copolymers of acrylates and methacrylates with fluoroalkenes	2011/01/25
7875286	Polycationic peptide coatings and methods of coating implantable medical devices	2011/01/25
7887871	Method and system for irradiation of a drug eluting implantable medical device	2011/02/15
7892592	Coating abluminal surfaces of stents and other implantable medical devices	2011/02/22
7901703	Polycationic peptides for cardiovascular therapy	2011/03/08
7919075	Coatings for implantable medical devices	2011/04/05
7976891	Abluminal stent coating apparatus and method of using focused acoustic energy	2011/07/12
7985440	Method of using a mandrel to coat a stent	2011/07/26
7989018	Fluid treatment of a polymeric coating on an implantable medical device	2011/08/02
8003156	Rotatable support elements for stents	2011/08/23
8007775	Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same	2011/08/30
8017140	Drug-delivery stent formulations for restenosis and vulnerable plaque	2011/09/13
8017141	Coatings of acrylamide-based copolymers	2011/09/13
8017142	Polysulfone block copolymers as drug-eluting coating material	2011/09/13
8021676	Functionalized chemically inert polymers for coatings	2011/09/20
8052912	Temperature controlled crimping	2011/11/08
8052988	Methods for fabricating coatings for drug delivery devices having gradient of hydration	2011/11/08
8067023	Implantable medical devices incorporating plasma polymerized film layers and charged amino acids	2011/11/29
8067025	Nitric oxide generating medical devices	2011/11/29
8069814	Stent support devices	2011/12/06
8110211	Medicated coatings for implantable medical devices including polyacrylates	2012/02/07
8110243	Coating for a stent and a method of forming the same	2012/02/07
8114150	RGD peptide attached to bioabsorbable stents	2012/02/14
8119184	Method of making a variable surface area stent	2012/02/21
8173199	40-O-(2-hydroxy)ethyl-rapamycin coated stent	2012/05/08
8192752	Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same	2012/06/05
8197879	Method for selectively coating surfaces of a stent	2012/06/12
8231962	Coatings for drug delivery devices having gradient of hydration	2012/07/31
8277926	Methods for fabricating coatings for drug delivery devices having gradient of hydration	2012/10/02
8293367	Nanoshells on polymers	2012/10/23
8293890	Hyaluronic acid based copolymers	2012/10/23
8303651	Polymeric coating for reducing the rate of release of a therapeutic substance from a stent	2012/11/06
8304012	Method for drying a stent	2012/11/06
8309112	Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same	2012/11/13
8357391	Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages	2013/01/22
8361539	Methods of forming microparticle coated medical device	2013/01/29
8465789	Rotatable support elements for stents	2013/06/18
8506617	Micronized peptide coated stent	2013/08/13
8563025	Coatings for implantable medical devices	2013/10/22
8568764	Methods of forming coating layers for medical devices utilizing flash vaporization	2013/10/29
8596215	Rotatable support elements for stents	2013/12/03
8597673	Coating of fast absorption or dissolution	2013/12/03
8603536	Microparticle coated medical device	2013/12/10
8609123	Derivatized poly(ester amide) as a biobeneficial coating	2013/12/17
8637110	Rotatable support elements for stents	2014/01/28
8685431	Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same	2014/04/01
8703167	Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug	2014/04/22
8741378	Methods of coating an implantable device	2014/06/03
8741379	Rotatable support elements for stents	2014/06/03
8778375	Amorphous poly(D,L-lactide) coating	2014/07/15
8778376	Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating	2014/07/15
8956640	Block copolymers including a methoxyethyl methacrylate midblock	2015/02/17
8961588	Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin	2015/02/24
9011831	Methacrylate copolymers for medical devices	2015/04/21
9028859	Phase-separated block copolymer coatings for implantable medical devices	2015/05/12
9084671	Methods of forming a micronized peptide coated stent	2015/07/21
9114198	Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same	2015/08/25
9175162	Methods for forming stent coatings comprising hydrophilic additives	2015/11/03
9345814	Methacrylate copolymers for medical devices	2016/05/24
9561309	Antifouling heparin coatings	2017/02/07
9561351	Drug delivery spiral coil construct	2017/02/07

Abbott Cardiovascular Systems (66)

Number	Title	Issue Date
7569655	Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same	2009/08/04
7601383	Coating construct containing poly (vinyl alcohol)	2009/10/13
7699889	Poly(ester amide) block copolymers	2010/04/20
7713541	Zwitterionic terpolymers, method of making and use on medical devices	2010/05/11
7749263	Poly(ester amide) filler blends for modulation of coating properties	2010/07/06
7927621	Thioester-ester-amide copolymers	2011/04/19
7985441	Purification of polymers for coating applications	2011/07/26
8017237	Nanoshells on polymers	2011/09/13
8025916	Methods for forming a composite stent with regioselective material	2011/09/27
8029816	Medical device coated with a coating containing elastin pentapeptide VGVPG	2011/10/04
8048441	Nanobead releasing medical devices	2011/11/01
8048448	Nanoshells for drug delivery	2011/11/01
8062350	RGD peptide attached to bioabsorbable stents	2011/11/22
8109904	Drug delivery medical devices	2012/02/07
8118863	RGD peptide attached to bioabsorbable stents	2012/02/21
8128983	Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network	2012/03/06
8147769	Stent and delivery system with reduced chemical degradation	2012/04/03
8333984	Coatings of acrylamide-based copolymers	2012/12/18
8431665	Zwitterionic terpolymers, method of making and use on medical devices	2013/04/30
8435550	Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device	2013/05/07
8551512	Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS	2013/10/08
8586069	Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders	2013/11/19
8586075	Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages	2013/11/19
8591934	Coatings of acrylamide-based copolymers	2013/11/26
8592036	Nanoshells on polymers	2013/11/26
8603530	Nanoshell therapy	2013/12/10
8603634	End-capped poly(ester amide) copolymers	2013/12/10
8642062	Implantable device having a slow dissolving polymer	2014/02/04
8647655	Biocompatible polyacrylate compositions for medical applications	2014/02/11
8673334	Stent coatings comprising hydrophilic additives	2014/03/18
8685430	Tailored aliphatic polyesters for stent coatings	2014/04/01
8697110	Polymers comprising amorphous terpolymers and semicrystalline blocks	2014/04/15
8697113	Coating comprising a terpolymer comprising caprolactone and glycolide	2014/04/15
8703169	Implantable device having a coating comprising carrageenan and a biostable polymer	2014/04/22
8722826	Zwitterionic terpolymers, method of making and use on medical devices	2014/05/13
8778014	Coatings for preventing balloon damage to polymer coated stents	2014/07/15
8791171	Biodegradable coatings for implantable medical devices	2014/07/29
8808342	Nanoshell therapy	2014/08/19
8871236	Biocompatible polyacrylate compositions for medical applications	2014/10/28
8871883	Biocompatible coating for implantable medical devices	2014/10/28
8883175	Block copolymers of acrylates and methacrylates with fluoroalkenes	2014/11/11
8889170	Implantable device having a coating with a triblock copolymer	2014/11/18
8916188	Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block	2014/12/23
8932615	Implantable devices formed on non-fouling methacrylate or acrylate polymers	2015/01/13
8952123	Dioxanone-based copolymers for implantable devices	2015/02/10
8961584	Composite stent with regioselective material	2015/02/24
8986726	Biocompatible polyacrylate compositions for medical applications	2015/03/24
9056155	Coatings having an elastic primer layer	2015/06/16
9067000	End-capped poly(ester amide) copolymers	2015/06/30
9090745	Biodegradable triblock copolymers for implantable devices	2015/07/28
9101697	Hyaluronic acid based copolymers	2015/08/11
9339592	Polymers of fluorinated monomers and hydrocarbon monomers	2016/05/17
9345668	Implantable device having a slow dissolving polymer	2016/05/24
9364498	Heparin prodrugs and drug delivery stents formed therefrom	2016/06/14
9375445	Heparin prodrugs and drug delivery stents formed therefrom	2016/06/28
9381279	Implantable devices formed on non-fouling methacrylate or acrylate polymers	2016/07/05
9446173	Block copolymers of acrylates and methacrylates with fluoroalkenes	2016/09/20
9468706	Phosphoryl choline coating compositions	2016/10/18
9468707	Biodegradable triblock copolymers for implantable devices	2016/10/18
9580558	Polymers containing siloxane monomers	2017/02/28
9629944	Implantable device with a triblock polymer coating	2017/04/25
9737638	Polyester amide copolymers having free carboxylic acid pendant groups	2017/08/22
9814553	Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating	2017/11/14
10064982	PDLLA stent coating	2018/09/04
10076591	Absorbable coating for implantable device	2018/09/18
10155881	Substituted polycaprolactone for coating	2018/12/18

SurModics (25)

Number	Title	Issue Date
6214901	Bioactive agent release coating	2001/04/10
6344035	Bioactive agent release coating	2002/02/05
6890583	Bioactive agent release coating	2005/05/10
7008667	Bioactive agent release coating	2006/03/07
7056533	Medicament incorporation matrix	2006/06/06
7097850	Bioactive agent release coating and controlled humidity method	2006/08/29
7442402	Bioactive agent release coating	2008/10/28
7541048	Coating compositions for bioactive agents	2009/06/02
7544673	Coating compositions for bioactive agents	2009/06/09
7691476	Hydrophilic polymeric coatings for medical articles	2010/04/06
7794751	Medicament incorporation matrix	2010/09/14
7824704	Controlled release bioactive agent delivery device	2010/11/02
7833548	Bioactive agent release coating and controlled humidity method	2010/11/16
7976862	Controlled release bioactive agent delivery device	2011/07/12
8021680	Controlled release bioactive agent delivery device	2011/09/20
8034369	Controlled release bioactive agent delivery device	2011/10/11
8163327	Hydrophilic polymeric coatings for medical articles	2012/04/24
8246974	Medical devices and methods for producing the same	2012/08/21
9308355	Apparatus and methods for coating medical devices	2016/04/12
9623215	Apparatus and methods for coating medical devices	2017/04/18
9827401	Apparatus and methods for coating medical devices	2017/11/28
10099041	Apparatus and methods for coating medical devices	2018/10/16
10507309	Apparatus and methods for coating medical devices	2019/12/17
11628466	Apparatus and methods for coating medical devices	2023/04/18
11819590	Apparatus and methods for coating medical devices	2023/11/21

Abbott Laboratories (16)

Number	Title	Issue Date
7781551	Zwitterionic copolymers, method of making and use on medical devices	2010/08/24
7910678	Copolymers having 1-methyl-2-methoxyethyl moieties	2011/03/22
7928176	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2011/04/19
7928177	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/04/19
8048975	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/11/01
8063151	Methods for manufacturing copolymers having 1-methyl-2-methoxyethyl moieties and use of same	2011/11/22
8071705	Amino acid mimetic copolymers and medical devices coated with the copolymers	2011/12/06
8101156	Methods of manufacturing copolymers with zwitterionic moieties and dihydroxyphenyl moieties and use of same	2012/01/24
8202956	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2012/06/19
8399584	Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers	2013/03/19
8465758	Drug delivery from stents	2013/06/18
8569435	Amino acid mimetic copolymers and medical devices coated with the copolymers	2013/10/29
8658749	Methods for manufacturing amino acid mimetic copolymers and use of same	2014/02/25
8753659	Drug delivery from stents	2014/06/17
8846839	Copolymers having zwitterionic moieties and dihdroxyphenyl moieties and medical devices coated with the copolymers	2014/09/30
9180225	Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties	2015/11/10

Innovatech, (16)

Number	Title	Issue Date
7147634	Electrosurgical electrode and method of manufacturing same	2006/12/12
7160297	Anti-microbial electrosurgical electrode and method of manufacturing the same	2007/01/09
7261925	Coating reinforcing underlayment and method of manufacturing same	2007/08/28
7288091	Anti-microbial electrosurgical electrode and method of manufacturing same	2007/10/30
7390326	Anti-microbial electrosurgical electrode and method of manufacturing same	2008/06/24
7618684	Method of forming a coating on a surface of a substrate	2009/11/17
7718212	Anti-microbial electrosurgical electrode and method of manufacturing same	2010/05/18
7838082	Method of forming a coating on a surface of a substrate	2010/11/23
7955637	Anti-microbial electrosurgical electrode and method of manufacturing same	2011/06/07
8814861	Electrosurgical electrode and method of manufacturing same	2014/08/26
8814862	Electrosurgical electrode and method of manufacturing same	2014/08/26
8814863	Electrosurgical electrode and method of manufacturing same	2014/08/26
8895133	Method of forming a coating on a surface of a substrate	2014/11/25
9630206	Electrosurgical electrode and method of manufacturing same	2017/04/25
10463420	Electrosurgical electrode and method of manufacturing same	2019/11/05
11246645	Electrosurgical electrode and method of manufacturing same	2022/02/15

Boston Scientific (15)

Number	Title	Issue Date
6638259	Biocompatible medical devices	2003/10/28
6663606	Biocompatible medical devices	2003/12/16
6908443	Intravascular guide wire and method for manufacture thereof	2005/06/21
7063674	Intravascular guide wire and method for manufacture thereof	2006/06/20
7214201	Intravascular guide wire and method for manufacture thereof	2007/05/08
7335264	Differentially coated medical devices, system for differentially coating medical devices, and coating method	2008/02/26
7674251	Medical devices including aerated adhesive bonds and methods of forming the same	2010/03/09
7951392	Microarray drug delivery coatings	2011/05/31
7955272	High performance coil wire	2011/06/07
8043278	Medical devices including aerated adhesive bonds and methods of forming the same	2011/10/25
8808272	Biocompatible medical devices	2014/08/19
11413170	Compositions, devices, kits and methods for attaching stent-containing medical devices to tissue	2022/08/16
11540857	Endovascular device with a tissue piercing distal probe and associated methods	2023/01/03
11992238	Endovascular device with a tissue piercing distal probe and associated methods	2024/05/28
12220334	Stent-containing medical devices and methods of using the same	2025/02/11

Novartis (12)

Number	Title	Issue Date
8939577	Silicone hydrogel lenses with water-rich surfaces	2015/01/27
8944592	Silicone hydrogel lens with a crosslinked hydrophilic coating	2015/02/03
9005700	Method for making UV-absorbing ophthalmic lenses	2015/04/14
9239409	Silicone hydrogel lens with a crosslinked hydrophilic coating	2016/01/19
9244200	Silicone hydrogel lenses with water-rich surfaces	2016/01/26
9411171	Silicone hydrogel lenses with water-rich surfaces	2016/08/09
9507173	Silicone hydrogel lens with a crosslinked hydrophilic coating	2016/11/29
9708087	Silicone hydrogel lens with a crosslinked hydrophilic coating	2017/07/18
9738813	Silicone hydrogel lens with a crosslinked hydrophilic coating	2017/08/22
9816009	Silicone hydrogel lenses with water-rich surfaces	2017/11/14
10338408	Method for making improved UV-absorbing ophthalmic lenses	2019/07/02
10449740	Method for applying stable coating on silicone hydrogel contact lenses	2019/10/22

C.R. Bard (12)

Number	Title	Issue Date
8070736	Waste management system	2011/12/06
8075539	Waste management system	2011/12/13
8597266	Waste management system	2013/12/03
8777912	Waste management system	2014/07/15
8926577	Waste management system	2015/01/06
9456920	Waste management system	2016/10/04
9463110	Waste management system	2016/10/11
9855163	Waste management system	2018/01/02
10660784	Waste management system	2020/05/26
10857324	Urinary catheter	2020/12/08
10874825	Urinary catheter	2020/12/29
11850370	Urinary catheter	2023/12/26

Cilag (8)

Number	Title	Issue Date
9034415	Surgical needle coatings and methods	2015/05/19
9221075	Surgical needle coatings and methods	2015/12/29
9259219	Surgical needle coatings and methods	2016/02/16
9266145	Surgical needle coatings and methods	2016/02/23
9332982	Surgical needle coatings and methods	2016/05/10
11197666	Surgical coated needles	2021/12/14
11717284	Surgical needle coatings and methods	2023/08/08
11832811	Surgical coated needles	2023/12/05

Alcon (7)

Number	Title	Issue Date
10781340	Silicone hydrogel lenses with water-rich surfaces	2020/09/22
10830923	Method for producing MPS-compatible water gradient contact lenses	2020/11/10
11001647	Soft silicone medical devices	2021/05/11
11002884	Method for applying stable coating on silicone hydrogel contact lenses	2021/05/11
11029446	Method for producing MPS-compatible water gradient contact lenses	2021/06/08
11029447	Method for producing MPS-compatible water gradient contact lenses	2021/06/08
11256003	Weekly and monthly disposable water gradient contact lenses	2022/02/22

IPXMEDICAL, LLC (6)

Number	Title	Issue Date
7771468	Medicated stent having multi-layer polymer coating	2010/08/10
7771468	Medicated stent having multi-layer polymer coating	2010/08/10
8101200	Targeted therapeutic agent release devices and methods of making and using the same	2012/01/24
8101200	Targeted therapeutic agent release devices and methods of making and using the same	2012/01/24
8287590	Medicated stent having multi-layer polymer coating	2012/10/16
8287590	Medicated stent having multi-layer polymer coating	2012/10/16

Hollister (5)

Number	Title	Issue Date
8323255	Bowel management system	2012/12/04
8801683	Bowel management system	2014/08/12
10617789	Hydrophilic coatings and methods of forming the same	2020/04/14
11529439	Lubricious hydrophilic coatings and methods of forming the same	2022/12/20
11623020	Hydrophilic coatings and methods of forming the same	2023/04/11

BridgePoint Medical (5)

Number	Title	Issue Date
8202246	Crossing occlusions in blood vessels	2012/06/19
8337425	Endovascular device with a tissue piercing distal probe and associated methods	2012/12/25
9872685	Crossing occlusions in blood vessels	2018/01/23
10575869	Endovascular device with a tissue piercing distal probe and associated methods	2020/03/03
11065002	Crossing occlusions in blood vessels	2021/07/20

Yeda Research and Development Co. (4)

Number	Title	Issue Date
10940111	Surface treatment by water-soluble polymers and lipids/liposomes	2021/03/09
11633358	Surface treatment by water-soluble polymers and lipids/liposomes	2023/04/25
11883533	Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes	2024/01/30
12274786	Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes	2025/04/15

Medtronic (3)

Number	Title	Issue Date
6273878	Shaft for medical catheters	2001/08/14
6756449	AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods	2004/06/29
7064168	A.sub.nB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods	2006/06/20

Ethicon (3)

Number	Title	Issue Date
7041088	Medical devices having durable and lubricious polymeric coating	2006/05/09
10004494	Surgical needle coatings and methods	2018/06/26
10939907	Surgical needle coatings and methods	2021/03/09

Biocompatibles UK (3)

Number	Title	Issue Date
7306625	Balloon expandable stent	2007/12/11
7794775	Balloon expandable stent	2010/09/14
8052746	Balloon expandable stent	2011/11/08

Angiotech International (3)

Number	Title	Issue Date
8313760	Compositions and methods for coating medical implants	2012/11/20
8372420	Compositions and methods for coating medical implants	2013/02/12
8425927	Compositions and methods for coating medical implants	2013/04/23

Innovative Surface Technologies (3)

Number	Title	Issue Date
9539371	Coating agents and coated articles	2017/01/10
10266620	Coating agents and coated articles	2019/04/23
10744233	Crystallization inhibitor compositions for implantable urological devices	2020/08/18

Biomet Manufacturing (2)

Number	Title	Issue Date
8776716	Surgical mesh spray and delivery system	2014/07/15
9345623	Surgical mesh spray and delivery system	2016/05/24

Johnson & Johnson (2)

Number	Title	Issue Date
6500481	Biomedical devices with amid-containing coatings	2002/12/31
6838491	Biomedical devices with hydrophilic coatings	2005/01/04

Scimed Life Systems (2)

Number	Title	Issue Date
7470239	High performance coil wire	2008/12/30
7946999	High performance coil wire	2011/05/24

ZB MANUFACTURING, LLC (2)

Number	Title	Issue Date
8776716	Surgical mesh spray and delivery system	2014/07/15
9345623	Surgical mesh spray and delivery system	2016/05/24

Biomet (2)

Number	Title	Issue Date
8776716	Surgical mesh spray and delivery system	2014/07/15
9345623	Surgical mesh spray and delivery system	2016/05/24

FujiFilm (1)

Number	Title	Issue Date
11351761	Composition for laminated material used for medical lubricating member, laminated material used for medical lubricating member, medical lubricating member, and medical device	2022/06/07

Abbott Cardiocascular Systems (1)

Number	Title	Issue Date
8758801	Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages	2014/06/24

Mitsubishi Polyester Film (1)

Number	Title	Issue Date
7384684	Polyester film with hydrophilic coating, process for its production and its use	2008/06/10

Endovascular Devices (1)

Number	Title	Issue Date
7396538	Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device	2008/07/08

abbott cardiovasular systems (1)

Number	Title	Issue Date
8109904	Drug delivery medical devices	2012/02/07

Zimmer (1)

Number	Title	Issue Date
6183516	Method for improved bonding of prosthetic devices to bone	2001/02/06

cardinal health switzerland 515 (1)

Number	Title	Issue Date
8133346	Medical device having bonding regions and method of making the same	2012/03/13

Shimadzu (1)

Number	Title	Issue Date
7175812	Automatic sampler and needle for the same	2007/02/13

SICPA (1)

Number	Title	Issue Date
10711168	Process for assembling elements containing biological substances	2020/07/14

Ecolab (1)

Number	Title	Issue Date
6591970	Water-activatable conveyor lubricant and method for transporting articles on a conveyor system	2003/07/15

COOK MEDICAL TECHNOLOGIES (1)

Number	Title	Issue Date
7914841	Inline application of coatings	2011/03/29

Terumo (1)

Number	Title	Issue Date
11872326	Medical instrument	2024/01/16

United Technologies (1)

Number	Title	Issue Date
10309018	Composite article having layer with co-continuous material regions	2019/06/04

SURGICAL SPECIALTIES (1)

Number	Title	Issue Date
6306176	Bonding layers for medical device surface coatings	2001/10/23

advanced cardiocasvular systems (1)

Number	Title	Issue Date
7967998	Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability	2011/06/28

MicroVention (1)

Number	Title	Issue Date
10350094	Implantable device with adhesive properties	2019/07/16

Keimar (1)

Number	Title	Issue Date
7630747	Apparatus for ascertaining blood characteristics and probe for use therewith	2009/12/08

Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
424	422	Emerging	Sustaining	Seminal	Medium	Average	52.2
424	475	Declining	Sustaining	Seminal	Medium	Average	64.7
424	482	Stable	Sustaining	Seminal	Medium	Average	68.9
427	2.3	Stable	Sustaining	Seminal	Medium	Average	68.3
604	12	Stable	Sustaining	Seminal	Medium	Average	56.5
604	265	Emerging	Average	Seminal	Medium	Average	60.6
623	901	Stable	Sustaining	Seminal	Medium	Average	65.3