Devices for tissue repair and methods for preparation and use thereof

Overview

Information

Number: 6280474
Application
Filing date: 07/27/1999
Issue date: 08/28/2001
Inventor(s): James J. Cassidy, Jeff E. Yeung, Jacqueline Anne Schroeder, Vivek Shenoy, Melissa K. C. Brown

US Classification: 606/232; 623/16.11

Citations

Angiotech International (13)

Number	Title	Issue Date
5110604	Processes for producing collagen matrixes and methods of using same	1992/05/05
5800541	Collagen-synthetic polymer matrices prepared using a multiple step reaction	1998/09/01
5580923	Anti-adhesion films and compositions for medical use	1996/12/03
5550187	Method of preparing crosslinked biomaterial compositions for use in tissue augmentation	1996/08/27
5527856	Method of preparing crosslinked biomaterial compositions for use in tissue augmentation	1996/06/18
5523348	Method of preparing collagen-polymer conjugates	1996/06/04
5475052	Collagen-synthetic polymer matrices prepared using a multiple step reaction	1995/12/12
5446091	Collagen-polymer conjugates containing an ether linkage	1995/08/29
5290552	Surgical adhesive material	1994/03/01
5413791	Collagen-polymer conjugates	1995/05/09
5376375	Method of augmenting tissue using collagen-polymer conjugates	1994/12/27
5328955	Collagen-polymer conjugates	1994/07/12
5306500	Method of augmenting tissue with collagen-polymer conjugates	1994/04/26

ANGIODEVICE INTERNATIONAL (4)

Number	Title	Issue Date
5162430	Collagen-polymer conjugates	1992/11/10
5304595	Collagen-polymer conjugates	1994/04/19
5324775	Biologically inert, biocompatible-polymer conjugates	1994/06/28
5643464	Process for preparing a sterile, dry crosslinking agent	1997/07/01

Cohesion Technologies (4)

Number	Title	Issue Date
4743229	Collagen/mineral mixing device and method	1988/05/10
4424208	Collagen implant material and method for augmenting soft tissue	1984/01/03
4488911	Non-antigenic collagen and articles of manufacture	1984/12/18
5428022	Composition of low type III content human placental collagen	1995/06/27

ALLERGAN (4)

Number	Title	Issue Date
4642117	Mechanically sheared collagen implant material and method	1987/02/10
4582640	Injectable cross-linked collagen implant material	1986/04/15
4803075	Injectable implant composition having improved intrudability	1989/02/07
5035715	Gamma irradiation of collagen/mineral mixtures	1991/07/30

NA (4)

Number	Title	Issue Date
5294249	Blendpolymers	1994/03/15
5709687	Fixation pin for small-bone fragments	1998/01/20
5489210	Expanding dental implant and method for its use	1996/02/06
5919193	Method and kit for surgically correcting malformations in digits of a finger or toe	1999/07/06

COLLAGEN (3)

Number	Title	Issue Date
4140537	Aqueous collagen composition	1979/02/20
4888366	Inductive collagen-based bone repair preparations	1989/12/19
4563350	Inductive collagen based bone repair preparations	1986/01/07

Massachusetts Institute Of Technology (2)

Number	Title	Issue Date
5837752	Semi-interpenetrating polymer networks	1998/11/17
4947840	Biodegradable templates for the regeneration of tissues	1990/08/14

Nitta Gelatin (1)

Number	Title	Issue Date
4533358	Process for producing a shaped product of collagen by syneresis	1985/08/06

Zimmer (1)

Number	Title	Issue Date
5478342	Reversible bone screw lock	1995/12/26

MEDTRONIC INTERNATIONAL, LTD. (1)

Number	Title	Issue Date
5709934	Bipolymer foams having extracellular matrix particulates	1998/01/20

Battelle Memorial Institute (1)

Number	Title	Issue Date
4544516	Collagen orientation	1985/10/01

Neucoll (1)

Number	Title	Issue Date
4795467	Xenogeneic collagen/mineral preparations in bone repair	1989/01/03

Vitaphore (1)

Number	Title	Issue Date
5322648	Process for forming shaped collagen devices	1994/06/21

basf beauty care solutions france sas (1)

Number	Title	Issue Date
4923380	Apparatus for the extrusion of collogen tubes	1990/05/08

Burroughs Wellcome Co. (1)

Number	Title	Issue Date
4410537	Pharmaceutical ethers	1983/10/18

REGENTS OF THE UNIVERSITY OF MICHIGAN, THE (1)

Number	Title	Issue Date
5501706	Medical implant structure and method for using the same	1996/03/26

MARIEL THERAPEUTICS, INC. (1)

Number	Title	Issue Date
6110482	Manufacture of autogenous replacement body parts	2000/08/29

ANGIOTECH BIOMATERIALS CORP. (1)

Number	Title	Issue Date
4776890	Preparation of collagen hydroxyapatite matrix for bone repair	1988/10/11

Baxter International (1)

Number	Title	Issue Date
5226877	Method and apparatus for preparing fibrinogen adhesive from whole blood	1993/07/13

ReGen Biologics (1)

Number	Title	Issue Date
5735902	Hand implant device	1998/04/07

VISION 2000 TECHNOLOGIES (1)

Number	Title	Issue Date
4164559	Collagen drug delivery device	1979/08/14

bonutti skeletal innovations (1)

Number	Title	Issue Date
5718717	Suture anchor	1998/02/17

Abstract

Abstract

Methods and implant devices for use in tissue repair. The implant devices include resorbable, swellable implant bodies, formed from a dehydrated crosslinked biocompatible polymer. The implant devices are capable of swelling after insertion into tissues to become anchored in place.

Assignees with Similar Patents

Angiotech International (18)

Number	Title
7176256	Biocompatible crosslinked composition
5204382	Injectable ceramic compositions and methods for their preparation and use
102122311	Methods and Crosslinked Polymer Compositions for Cartilage Repair
5306500	Method of augmenting tissue with collagen-polymer conjugates
6962979	Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
5308889	Dehydrated collagen-polymer strings
5292802	Collagen-polymer tubes for use in vascular surgery
5800541	Collagen-synthetic polymer matrices prepared using a multiple step reaction
5752974	Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
5328955	Collagen-polymer conjugates
5550188	Polymer conjugates ophthalmic devices comprising collagen-polymer conjugates
5543441	Implants coated with collagen-polymer conjugates
5523348	Method of preparing collagen-polymer conjugates
5352715	Injectable ceramic compositions and methods for their preparation and use
5475052	Collagen-synthetic polymer matrices prepared using a multiple step reaction
5446091	Collagen-polymer conjugates containing an ether linkage
5413791	Collagen-polymer conjugates
5376375	Method of augmenting tissue using collagen-polymer conjugates

ANGIODEVICE INTERNATIONAL (7)

Number	Title
5304595	Collagen-polymer conjugates
5324775	Biologically inert, biocompatible-polymer conjugates
5162430	Collagen-polymer conjugates
5614587	Collagen-based bioadhesive compositions
6166130	Method of using crosslinked polymer compositions in tissue treatment applications
5264214	Composition for bone repair
6534591	Cross-linked polymer compositions and methods for their use

Organogenesis (4)

Number	Title
101075567	Method for treating diseased or damaged organs
101296452	Tissue Repair Fabric
7909886	Tissue repair fabric
7060103	Tissue repair fabric

SURGICAL SPECIALTIES (3)

Number	Title
6280474	Devices for tissue repair and methods for preparation and use thereof
7129209	Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions
6083522	Devices for tissue repair and methods for preparation and use thereof

ALLERGAN (3)

Number	Title
102396140	CROSS-LINKED COLLAGEN AND USES THEREOF
102390665	Cross-Linked Collagen and Uses Thereof
101810103	Cross-linked collagen and uses thereof

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10813764	Expandable introducer system and methods	2020/10/27
10869728	Robotic surgery	2020/12/22
10932869	Robotic surgery	2021/03/02
10959791	Robotic surgery	2021/03/30
11013542	Tissue fixation system and method	2021/05/25
11129645	Methods of securing a fastener	2021/09/28
11134995	Method and devices for intracorporeal bonding of implants with thermal energy	2021/10/05
11219446	Deformable fastener system	2022/01/11
11246638	Methods and devices for utilizing bondable materials	2022/02/15
11253296	Methods and devices for intracorporeal bonding of implants with thermal energy	2022/02/22
11278331	Method and devices for intracorporeal bonding of implants with thermal energy	2022/03/22
11317974	Systems and methods for navigation and visualization	2022/05/03
11457958	Devices and methods for stabilizing tissue and implants	2022/10/04
11684430	Systems and methods for navigation and visualization	2023/06/27
11744651	Systems and methods for navigation and visualization	2023/09/05
11801044	Tissue fixation system and method	2023/10/31
11992205	Devices and methods for stabilizing tissue and implants	2024/05/28
11998251	Methods and devices for intracorporeal bonding of implants with thermal energy	2024/06/04
12023111	Systems and methods for navigation and visualization	2024/07/02
12096995	Systems and methods for navigation and visualization	2024/09/24
12137898	Tissue fixation system and method	2024/11/12
12232789	Methods and devices for utilizing bondable materials	2025/02/25
12268455	Systems and methods for navigation and visualization	2025/04/08

ArthroSurface (61)

Number	Title	Issue Date
7510558	System and method for joint resurface repair	2009/03/31
7604641	System and method for joint resurface repair	2009/10/20
7618462	System and method for joint resurface repair	2009/11/17
7678151	System and method for joint resurface repair	2010/03/16
7713305	Articular surface implant	2010/05/11
7828853	Articular surface implant and delivery system	2010/11/09
7857817	System and method for joint resurface repair	2010/12/28
7896883	Bone resurfacing system and method	2011/03/01
7896885	Retrograde delivery of resurfacing devices	2011/03/01
7901408	System and method for retrograde procedure	2011/03/08
7914545	System and method for retrograde procedure	2011/03/29
7951163	Retrograde excision system and apparatus	2011/05/31
8147559	System and method for joint resurface repair	2012/04/03
8177841	System and method for joint resurface repair	2012/05/15
8361159	System for articular surface replacement	2013/01/29
8388624	Trochlear resurfacing system and method	2013/03/05
8523872	Tibial resurfacing system	2013/09/03
8540717	System and method for joint resurface repair	2013/09/24
8556902	System and method for retrograde procedure	2013/10/15
8663230	Retrograde delivery of resurfacing devices	2014/03/04
8864827	System and method for joint resurface repair	2014/10/21
8926615	System and method for retrograde procedure	2015/01/06
8961614	Articular surface implant and delivery system	2015/02/24
9044343	System for articular surface replacement	2015/06/02
9055955	Bone resurfacing system and method	2015/06/16
9066716	Suture coil and suture sheath for tissue repair	2015/06/30
9204873	System and method for joint resurface repair	2015/12/08
9283076	Glenoid resurfacing system and method	2016/03/15
9351745	Trochlear resurfacing system and method	2016/05/31
9357989	System and method for joint resurface repair	2016/06/07
9358029	Retrograde resection apparatus and method	2016/06/07
9468448	System and method for joint resurfacing and repair	2016/10/18
9492200	Suture system and method	2016/11/15
9662126	Glenoid resurfacing system and method	2017/05/30
9861492	Anchor for an implant assembly	2018/01/09
9931211	Trochlear resurfacing system and method	2018/04/03
9931219	Implant and anchor assembly	2018/04/03
9962265	System and method for repairing articular surfaces	2018/05/08
10045788	Retrograde resection apparatus and method	2018/08/14
10076343	System for articular surface replacement	2018/09/18
10307172	System and method for joint resurfacing and repair	2019/06/04
10478200	Glenoid resurfacing system and method	2019/11/19
10575957	Anchor for an implant assembly	2020/03/03
10624748	System and method for repairing articular surfaces	2020/04/21
10624749	Trochlear resurfacing system and method	2020/04/21
10624752	Tibial resurfacing system and method	2020/04/21
10624754	System and method for repairing articular surfaces	2020/04/21
10695096	Suture system and method	2020/06/30
10945743	Glenoid repair system and methods of use thereof	2021/03/16
10959740	Retrograde resection apparatus and method	2021/03/30
11083587	Implant and anchor assembly	2021/08/10
11160663	Multicomponent articular surface implant	2021/11/02
11191552	System and method for joint resurfacing and repair	2021/12/07
11337819	Trochlear resurfacing system and method	2022/05/24
11471289	Tibial resurfacing system and method	2022/10/18
11478259	Glenoid resurfacing system and method	2022/10/25
11478358	Humeral and glenoid articular surface implant systems and methods	2022/10/25
11607319	System and method for repairing articular surfaces	2023/03/21
11648036	Suture system and method	2023/05/16
11712276	System and method for bone fixation	2023/08/01
11766334	System and method for repairing articular surfaces	2023/09/26

ArthroCare (29)

Number	Title	Issue Date
7090690	Devices and methods for repairing soft tissue	2006/08/15
7247164	Methods for attaching connective tissues to bone using a multi-component bone anchor	2007/07/24
7556640	Bone anchor device having toggle member for attaching connective tissues to bone	2009/07/07
7615061	Bone anchor suture-loading system, method and apparatus	2009/11/10
7637926	Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device	2009/12/29
7674274	Method and apparatus for attaching connective tissues to bone using a cortical bone anchoring device	2010/03/09
7682374	Knotless suture lock and bone anchor implant method	2010/03/23
7695494	Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device	2010/04/13
7963972	Implant and delivery system for soft tissue repair	2011/06/21
8105343	Independent suture tensioning and snaring apparatus	2012/01/31
8109966	Methods for attaching connective tissues to bone using a multi-component anchor	2012/02/07
8133258	Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device	2012/03/13
8137381	Knotless suture anchor having discrete polymer components and related methods	2012/03/20
8317829	Method and apparatus for attaching connective tissues to bone using a knotless suture anchoring device	2012/11/27
8425536	Implant and delivery system for soft tissue repair	2013/04/23
8444672	Methods and devices for attaching connective tissues to bone using a knotless suture anchoring device	2013/05/21
8617186	Independent suture tensioning and snaring apparatus	2013/12/31
8657854	Knotless suture anchoring device having deforming section to accommodate sutures of various diameters	2014/02/25
8685060	Methods and devices for attaching connective tissues to bone using a knotless suture anchoring device	2014/04/01
8828029	Independent suture tensioning and snaring apparatus	2014/09/09
8834495	Independent suture tensioning and snaring apparatus	2014/09/16
9023083	Method for soft tissue repair with free floating suture locking member	2015/05/05
9034014	Free floating wedge suture anchor for soft tissue repair	2015/05/19
9186133	Bone anchor insertion device	2015/11/17
9198649	Rotating locking member suture anchor and method for soft tissue repair	2015/12/01
9226742	Restricted wedge suture anchor and method for soft tissue repair	2016/01/05
9364210	Biased wedge suture anchor and method for soft tissue repair	2016/06/14
9636101	Bone anchor having an integrated stress isolator	2017/05/02
9855028	Multi-suture knotless anchor for attaching tissue to bone and related method	2018/01/02

Arthrex (24)

Number	Title	Issue Date
7160305	Retrodrill technique for insertion of autograft, allograft or synthetic osteochondral implants	2007/01/09
7862567	Retrodrill technique for insertion of autograft, allograft or synthetic osteochondral implants	2011/01/04
8430909	Knotless graft fixation using an implant having a pointed tip	2013/04/30
8668738	Method and apparatus for ACL reconstruction using retrograde cutter	2014/03/11
8801755	Suture anchor	2014/08/12
8821541	Suture anchor with insert-molded rigid member	2014/09/02
8939980	System for ACL reconstruction using retrograde cutter	2015/01/27
9179907	Knotless graft fixation assembly	2015/11/10
9521999	Fully-threaded bioabsorbable suture anchor	2016/12/20
9526493	Suture anchor with insert-molded rigid member	2016/12/27
9549726	Suture anchor with insert-molded rigid member	2017/01/24
9622739	Suture anchor	2017/04/18
9700297	Laminated surgical device	2017/07/11
9706986	Knotless suture and tissue securing method	2017/07/18
9770278	Dual tip guide wire	2017/09/26
9775599	Knotless tissue fixation assembly	2017/10/03
9814499	Intramedullary fracture fixation devices and methods	2017/11/14
10052091	Knotless suture or tissue fixation using an implant having a pointed tip	2018/08/21
10537319	Suture anchor	2020/01/21
10548648	Intramedullary fracture fixation devices and methods	2020/02/04
10595847	Fully-threaded bioabsorbable suture anchor	2020/03/24
10709436	Graft fixation using a plug against suture	2020/07/14
11324493	Fully-threaded bioabsorbable suture anchor	2022/05/10
12064104	Fully-threaded bioabsorbable suture anchor	2024/08/20

mimedx group (17)

Number	Title	Issue Date
8367148	Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches	2013/02/05
8986378	Implantable collagen devices and related methods and systems of making same	2015/03/24
9078775	Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches	2015/07/14
9125759	Biocomposite medical constructs including artificial tissues, vessels and patches	2015/09/08
9179976	Methods of making collagen fiber medical constructs and related medical constructs, including tubes	2015/11/10
9216077	Medical constructs of twisted lengths of collagen fibers and methods of making same	2015/12/22
9636209	Collagen fiber ribbons with integrated fixation sutures and methods of making the same	2017/05/02
9681869	Biostaples suitable for wrist, hand and other ligament replacements or repairs	2017/06/20
9694106	Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods	2017/07/04
9801978	Medical constructs including tubes and collagen fibers	2017/10/31
9873861	Methods of making implantable collagen fiber	2018/01/23
10149918	Medical constructs of twisted lengths of collagen fibers and methods of making same	2018/12/11
10238773	Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches	2019/03/26
10258327	Biostaples suitable for wrist, hand and other ligament replacements or repairs	2019/04/16
10653514	Collagen fiber ribbons with integrated fixation sutures and methods of making the same	2020/05/19
10689621	Kits and materials for implantable collagen devices	2020/06/23
10933161	Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods	2021/03/02

conventus orthopaedics (15)

Number	Title	Issue Date
8287538	Apparatus and methods for fracture repair	2012/10/16
8906022	Apparatus and methods for securing a bone implant	2014/12/09
8961518	Apparatus and methods for bone access and cavity preparation	2015/02/24
9517093	Apparatus and methods for fracture repair	2016/12/13
9730739	Rotary-rigid orthopaedic rod	2017/08/15
9788870	Apparatus and methods for fracture repair	2017/10/17
9795430	Apparatus and methods for securing a bone implant	2017/10/24
9848889	Apparatus and methods for bone access and cavity preparation	2017/12/26
9924990	Apparatus and methods for securing a bone implant	2018/03/27
9993277	Apparatus and methods for securing a bone implant	2018/06/12
10022132	Tissue displacement tools and methods	2018/07/17
10076342	Tissue displacement tools and methods	2018/09/18
10603087	Apparatus and methods for fracture repair	2020/03/31
10918426	Apparatus and methods for treatment of a bone	2021/02/16
11399878	Apparatus and methods for fracture repair	2022/08/02

Biomet Manufacturing (14)

Number	Title	Issue Date
8002778	Crosspin and method for inserting the same during soft ligament repair	2011/08/23
8147546	Method and apparatus for graft fixation	2012/04/03
8500818	Knee prosthesis assembly with ligament link	2013/08/06
8506597	Method and apparatus for interosseous membrane reconstruction	2013/08/13
8777956	Chondral defect repair	2014/07/15
8784489	Method and apparatus for graft fixation	2014/07/22
8900301	Method and apparatus for graft fixation	2014/12/02
8900314	Method of implanting a prosthetic knee joint assembly	2014/12/02
9414925	Method of implanting a knee prosthesis assembly with a ligament link	2016/08/16
9445827	Method and apparatus for intraosseous membrane reconstruction	2016/09/20
9700291	Capsule retractor	2017/07/11
9724090	Method and apparatus for attaching soft tissue to bone	2017/08/08
9757119	Visual aid for identifying suture limbs arthroscopically	2017/09/12
10149767	Method of implanting knee prosthesis assembly with ligament link	2018/12/11

3 D MATRIX (13)

Number	Title	Issue Date
10814038	Combination compositions	2020/10/27
10245299	Autoassembling peptides for the treatment of pulmonary bulla	2019/04/02
10369237	Sterilization and filtration of peptide compositions	2019/08/06
10576123	Tissue occluding agent comprising an IEIKIEIKIEIKI peptide	2020/03/03
10596225	Tissue occluding agent comprising an IEIKIEIKIEIKI peptide	2020/03/24
10654893	Self-assembling peptide compositions	2020/05/19
10793307	Fill-finish process for peptide solutions	2020/10/06
11090398	Sterilization and filtration of peptide compositions	2021/08/17
11324703	Surfactant peptide nanostructures and uses thereof in drug delivery	2022/05/10
11801281	Tissue occluding agent comprising an ieikieikieiki peptide	2023/10/31
12006085	Fill-finish process for peptide solutions	2024/06/11
12115264	Sterilization and filtration of peptide compositions	2024/10/15
12239744	Surfactant peptide nanostructures and uses thereof in drug delivery	2025/03/04

zimmer knee creations (13)

Number	Title	Issue Date
8062364	Osteoarthritis treatment and device	2011/11/22
8551178	Osteoarthritis treatment and device	2013/10/08
8574303	Osteoarthritis treatment and device	2013/11/05
8882848	Osteoarthritis treatment and device	2014/11/11
8998998	Osteoarthritis treatment and device	2015/04/07
9283014	Osteoarthritis treatment and device	2016/03/15
9439703	Osteoarthritis treatment and device	2016/09/13
9636161	Osteoarthritis treatment and device	2017/05/02
9757239	Osteoarthritis treatment and device	2017/09/12
9956082	Osteoarthritis treatment and device	2018/05/01
10182916	Osteoarthritis treatment and device	2019/01/22
10792159	Osteoarthritis treatment and device	2020/10/06
11351035	Osteoarthritis treatment and device	2022/06/07

SCOTT, W. TATE (12)

Number	Title	Issue Date
7585311	System and method for attaching soft tissue to bone	2009/09/08
8062334	Suture anchor	2011/11/22
8100942	System and method for attaching soft tissue to bone	2012/01/24
8109969	System and method for attaching soft tissue to bone	2012/02/07
8267964	System and method for attaching soft tissue to bone	2012/09/18
8512378	Suture anchor	2013/08/20
8529601	System and method for attaching soft tissue to bone	2013/09/10
8926663	System and method for attaching soft tissue to bone	2015/01/06
8951287	System and method for attaching soft tissue to bone	2015/02/10
9044226	System and method for attaching soft tissue to bone	2015/06/02
9414835	System and method for attaching soft tissue to bone	2016/08/16
9655611	System and method for attaching soft tissue to bone	2017/05/23

Children's Medical Center (11)

Number	Title	Issue Date
9308242	Methods and products for tissue repair	2016/04/12
9757495	Collagen scaffolds	2017/09/12
9849213	Methods and products for tissue repair	2017/12/26
10786232	Methods and procedures for ligament repair	2020/09/29
10786238	Methods and procedures for ligament repair	2020/09/29
10786239	Methods and procedures for ligament repair	2020/09/29
10842914	Collagen scaffolds	2020/11/24
11076845	Methods and procedures for ligament repair	2021/08/03
11076846	Methods and procedures for ligament repair	2021/08/03
11826489	Collagen scaffolds	2023/11/28
11839696	Collagen scaffolds	2023/12/12

SONOMA ORTHOPEDIC PRODUCTS (11)

Number	Title	Issue Date
7846162	Minimally invasive actuable bone fixation devices	2010/12/07
7909825	Fracture fixation device, tools and methods	2011/03/22
7914533	Minimally invasive actuable bone fixation devices	2011/03/29
7942875	Methods of using minimally invasive actuable bone fixation devices	2011/05/17
8287539	Fracture fixation device, tools and methods	2012/10/16
8287541	Fracture fixation device, tools and methods	2012/10/16
8439917	Fracture fixation device, tools and methods	2013/05/14
8961516	Straight intramedullary fracture fixation devices and methods	2015/02/24
9060820	Segmented intramedullary fracture fixation devices and methods	2015/06/23
9155574	Bone fixation device, tools and methods	2015/10/13
9259250	Fracture fixation device, tools and methods	2016/02/16

The Foundry, (11)

Number	Title	Issue Date
9278004	Method and apparatus for altering biomechanics of the articular joints	2016/03/08
9468466	Method and apparatus for altering biomechanics of the spine	2016/10/18
9668868	Apparatus and methods for treatment of patellofemoral conditions	2017/06/06
9795410	Method and apparatus for force redistribution in articular joints	2017/10/24
9861408	Method and apparatus for treating canine cruciate ligament disease	2018/01/09
9931136	Method and apparatus for altering biomechanics of articular joints	2018/04/03
10349980	Method and apparatus for altering biomechanics of the shoulder	2019/07/16
10695094	Method and apparatus for altering biomechanics of articular joints	2020/06/30
10898237	Method and apparatus for altering biomechanics of the spine	2021/01/26
11517360	Method and apparatus for treating canine cruciate ligament disease	2022/12/06
11730519	Method and apparatus for force redistribution in articular joints	2023/08/22

BIOMET U.S. RECONSTRUCTION, LLC (9)

Number	Title	Issue Date
8002778	Crosspin and method for inserting the same during soft ligament repair	2011/08/23
8147546	Method and apparatus for graft fixation	2012/04/03
8506597	Method and apparatus for interosseous membrane reconstruction	2013/08/13
8777956	Chondral defect repair	2014/07/15
8784489	Method and apparatus for graft fixation	2014/07/22
8900301	Method and apparatus for graft fixation	2014/12/02
9445827	Method and apparatus for intraosseous membrane reconstruction	2016/09/20
9700291	Capsule retractor	2017/07/11
9757119	Visual aid for identifying suture limbs arthroscopically	2017/09/12

Biomet (9)

Number	Title	Issue Date
8002778	Crosspin and method for inserting the same during soft ligament repair	2011/08/23
8147546	Method and apparatus for graft fixation	2012/04/03
8506597	Method and apparatus for interosseous membrane reconstruction	2013/08/13
8777956	Chondral defect repair	2014/07/15
8784489	Method and apparatus for graft fixation	2014/07/22
8900301	Method and apparatus for graft fixation	2014/12/02
9445827	Method and apparatus for intraosseous membrane reconstruction	2016/09/20
9700291	Capsule retractor	2017/07/11
9757119	Visual aid for identifying suture limbs arthroscopically	2017/09/12

ZB MANUFACTURING, LLC (9)

Number	Title	Issue Date
8002778	Crosspin and method for inserting the same during soft ligament repair	2011/08/23
8147546	Method and apparatus for graft fixation	2012/04/03
8506597	Method and apparatus for interosseous membrane reconstruction	2013/08/13
8777956	Chondral defect repair	2014/07/15
8784489	Method and apparatus for graft fixation	2014/07/22
8900301	Method and apparatus for graft fixation	2014/12/02
9445827	Method and apparatus for intraosseous membrane reconstruction	2016/09/20
9700291	Capsule retractor	2017/07/11
9757119	Visual aid for identifying suture limbs arthroscopically	2017/09/12

Shriners Hospitals for Children (7)

Number	Title	Issue Date
7901455	Tendon or ligament bioprostheses and methods of making same	2011/03/08
8177839	Woven and/or braided fiber implants and methods of making same	2012/05/15
8858633	In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers	2014/10/14
9393105	In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers	2016/07/19
9603968	Methods of making high-strength NDGA polymerized collagen fibers and related collagen-prep methods, medical devices and constructs	2017/03/28
9888996	In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers	2018/02/13
10472409	Methods of making high-strength NDGA polymerized collagen fibers and related collagen-prep methods, medical devices and constructs	2019/11/12

Warsaw Orthopedic (7)

Number	Title	Issue Date
7052497	Techniques for spinal surgery and attaching constructs to vertebral elements	2006/05/30
7172629	Osteogenic paste compositions and uses thereof	2007/02/06
7572291	Osteochondral repair assembly including retracting spacer, kit and method	2009/08/11
8012187	Techniques for spinal surgery and attaching constructs to vertebral elements	2011/09/06
8101676	Osteogenic paste compositions and uses thereof	2012/01/24
8177845	Osteogenic packing device and method	2012/05/15
8303632	Techniques for spinal surgery and attaching constructs to vertebral elements	2012/11/06

Biomet (7)

Number	Title	Issue Date
8641418	Titanium nano-scale etching on an implant surface	2014/02/04
9034201	Titanium nano-scale etching on an implant surface	2015/05/19
9131995	Surface treatment for an implant surface	2015/09/15
9283056	Titanium nano-scale etching on an implant surface	2016/03/15
9757212	Titanium nano-scale etching on an implant surface	2017/09/12
10182887	Titanium nano-scale etching on an implant surface	2019/01/22
10765494	Titanium nano-scale etching on an implant surface	2020/09/08

ZKR ORTHOPEDICS, INC. (5)

Number	Title	Issue Date
9808287	Method and system for patella tendon realignment	2017/11/07
10918415	Method and system for patella tendon realignment	2021/02/16
10918416	Method and system for patella tendon realignment	2021/02/16
11896476	Patella tendon realignment implant with changeable shape	2024/02/13
12303396	Adjustable patellar tendon realignment implant	2025/05/20

Smith & Nephew (5)

Number	Title	Issue Date
8529610	Tissue repair assembly	2013/09/10
8858606	Tissue repair assembly	2014/10/14
9241783	Arthroscopic biceps tenodesis repair	2016/01/26
9408690	Tissue repair assembly	2016/08/09
9913710	Implantable biologic holder	2018/03/13

Covidien (4)

Number	Title	Issue Date
9271706	Medical device for wound closure and method of use	2016/03/01
9943302	Medical device for wound closure and method of use	2018/04/17
10722224	Medical device for wound closure and method of use	2020/07/28
11013504	Medical device for wound closure and method of use	2021/05/25

COOK MEDICAL TECHNOLOGIES (4)

Number	Title	Issue Date
10441256	Devices and methods useful for sealing bodily openings	2019/10/15
10070850	Vascular closure with multiple connections	2018/09/11
10729416	Vascular closure with shape memory characteristic	2020/08/04
11317901	Vascular closure with multiple connections	2022/05/03

Depuy Mitek (4)

Number	Title	Issue Date
8133257	Bioabsorbable suture anchor system for use in small joints	2012/03/13
8613756	Knotless suture anchor	2013/12/24
9078646	Knotless suture anchor	2015/07/14
9855030	Knotless suture anchor	2018/01/02

Cayenne Medical (4)

Number	Title	Issue Date
11534155	Systems and methods for repairing soft tissues using nanofiber material	2022/12/27
11759198	Systems and methods for repairing soft tissues using nanofiber material	2023/09/19
12185933	Systems and methods for repairing soft tissues	2025/01/07
12185937	Systems and methods for repairing soft tissues using nanofiber material	2025/01/07

bonutti skeletal innovations (4)

Number	Title	Issue Date
6955683	Tissue fixation device	2005/10/18
8808329	Apparatus and method for securing a portion of a body	2014/08/19
8814902	Method of securing body tissue	2014/08/26
8845699	Method of securing tissue	2014/09/30

MEDOS INTERNATIONAL SARL (3)

Number	Title	Issue Date
10940016	Expandable intervertebral fusion cage	2021/03/09
12023258	Expandable intervertebral fusion cage	2024/07/02
12090064	Stabilization members for expandable intervertebral implants, and related systems and methods	2024/09/17

The Johns Hopkins University (3)

Number	Title	Issue Date
11771807	Nanofiber-hydrogel composites for cell and tissue delivery	2023/10/03
12036339	Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration	2024/07/16
12161781	Nanofiber-hydrogel composites for cell and tissue delivery	2024/12/10

Zimmer (3)

Number	Title	Issue Date
8613938	Bone void fillers	2013/12/24
8690874	Composition and process for bone growth and repair	2014/04/08
8742072	Bone growth particles and osteoinductive composition thereof	2014/06/03

Keraplast Technologies, (3)

Number	Title	Issue Date
6914126	Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks	2005/07/05
7001987	Hydrogel with controllable mechanical, chemical, and biological properties and method for making same	2006/02/21
9045600	Biopolymer materials	2015/06/02

ADVANCED SKELETAL INNOVATIONS LLC (3)

Number	Title	Issue Date
8808329	Apparatus and method for securing a portion of a body	2014/08/19
8814902	Method of securing body tissue	2014/08/26
8845699	Method of securing tissue	2014/09/30

alaska hand research (2)

Number	Title	Issue Date
8679168	Cannulated anchor and system	2014/03/25
8715348	Method and device for stabilizing joints with limited axial movement	2014/05/06

DePuy Products (2)

Number	Title	Issue Date
7354627	Method for organizing the assembly of collagen fibers and compositions formed therefrom	2008/04/08
7383164	System and method for designing a physiometric implant system	2008/06/03

DePuy Spine (2)

Number	Title	Issue Date
8133257	Bioabsorbable suture anchor system for use in small joints	2012/03/13
8613756	Knotless suture anchor	2013/12/24

DEPUY SYNTHES SALES, INC (2)

Number	Title	Issue Date
8133257	Bioabsorbable suture anchor system for use in small joints	2012/03/13
8613756	Knotless suture anchor	2013/12/24

Medicinelodge (2)

Number	Title	Issue Date
8771352	Method and apparatus for tibial fixation of an ACL graft	2014/07/08
9216078	Method and apparatus for tibial fixation of an ACL graft	2015/12/22

Ethicon (1)

Number	Title	Issue Date
9011487	Barbed sutures having pledget stoppers and methods therefor	2015/04/21

biedermann technology (1)

Number	Title	Issue Date
8216274	Longitudinal member for use in spinal or trauma surgery and stabilization device with such a longitudinal member	2012/07/10

Boston Scientific (1)

Number	Title	Issue Date
8709038	Puncture hole sealing device	2014/04/29

PTS (1)

Number	Title	Issue Date
7048963	Layered aligned polymer structures and methods of making same	2006/05/23

karl storz se (1)

Number	Title	Issue Date
8287577	Pin for fixing an implant subjected to tensile load	2012/10/16

MAKO SURGICAL (1)

Number	Title	Issue Date
11013602	Scaffold for alloprosthetic composite implant	2021/05/25

SDGI (1)

Number	Title	Issue Date
7550011	Osteogenic packing device and method	2009/06/23

Nobel Biocare Services (1)

Number	Title	Issue Date
7004974	Material for bone reconstruction	2006/02/28

Cook Biotech (1)

Number	Title	Issue Date
10441256	Devices and methods useful for sealing bodily openings	2019/10/15

SINCLAIR PHARMACEUTICALS (1)

Number	Title	Issue Date
7582105	Suture for wound closure, tissue approximation, tissue support, suspension and/or fixation	2009/09/01

flower orthopedics (1)

Number	Title	Issue Date
11596419	Plating depth gauge and countersink instrument	2023/03/07

vicus therapeutics (1)

Number	Title	Issue Date
10814038	Combination compositions	2020/10/27

biostructures (1)

Number	Title	Issue Date
8551525	Bone graft materials and methods	2013/10/08

Kfx Medical (1)

Number	Title	Issue Date
10561409	System and method for attaching soft tissue to bone	2020/02/18

Applied Medical Resources (1)

Number	Title	Issue Date
6589208	Self-deploying catheter assembly	2003/07/08

EIT EMERGING IMPLANT TECHNOLOGIES GMBH (1)

Number	Title	Issue Date
11510788	Expandable, angularly adjustable intervertebral cages	2022/11/29

BIOVENTUS LLC (1)

Number	Title	Issue Date
9220596	Bone graft materials and methods	2015/12/29

APPLIED MEDICAL RESOURSES (1)

Number	Title	Issue Date
6589208	Self-deploying catheter assembly	2003/07/08

LIGHTY, CRAIG E. (1)

Number	Title	Issue Date
7101862	Hemostatic compositions and methods for controlling bleeding	2006/09/05

arthtrex (1)

Number	Title	Issue Date
10716556	Knotless tissue fixation assembly	2020/07/21

Tech Analysis

Class	Subclass	Type	Reference Factor	Citation Factor	Strength	Grant time	Early grant (%)
606	232	Emerging	Average	Seminal	Medium High	Average	25.8
623	16.11	Emerging	Average	Seminal	Medium	Average	30.9